36. DANIELLE-CHRISTINE ZAMMIT
Information acquired: 2025
DANIELLE-CHRISTINE ZAMMIT is an academic who published a paper in 1997 entitled Studies on the role of cAMP and its activation of cAMP-dependent protein kinase in the mediation of. DANIELLE-CHRISTINE ZAMMIT published this work as part of a team: Zammit, Danielle Christine. Here is a description of this work: The,,adenosine 3', 5'-cyclic monophosphate (cAMP) activation of cAMP-dependent protein kinase (PKA), and its resultant effect on vascular smooth muscle tone was investigated. Isoproterenol (ISO) and prostaglandin Eâ‚ (PGEâ‚) have both been shown to elevate cAMP in vascular smooth muscle, the increase being accompanied by relaxation with ISO and contraction with P G E T. The activation of different pools of PKA by these drugs has been suggested to explain a similar observation in cardiomyocytes, where both ISO and PGEâ‚ elevated cAMP, yet only ISO increased contractility. To determine whether the circumstances in vascular smooth muscle were analogous to those in cardiac tissue, the study investigated the elevation of cAMP and the activation of PKA in subcellular fractions of vascular preparations treated with 1.