4. JOSHUA-M. SCURLL
Information acquired: 2025
JOSHUA-M. SCURLL is an academic who published a paper in 2021 entitled New methods for cluster analysis and their applications to the biology of B cells and diffuse large. JOSHUA-M. SCURLL published this work as part of a team: Scurll, Joshua M.. Here is a description of this work: Detecting clusters of data points in physical or high-dimensional (HD) space is a common task in biology and biomedicine. Single-molecule localization microscopy (SMLM), a category of super-resolution microscopy, is often used to analyze spatial distributions of proteins on the surface membranes of, or inside, biological cells. Proteins sometimes need to form clusters to surpass a critical signalling threshold for functional activity. Therefore, investigating protein clustering can yield important insights about protein and cell functions in health and disease. Mass cytometry, also called CyTOF, is a high-throughput technique for investigating the abundance of multiple proteins simultaneously in single cells, resulting in HD data in which cells cluster into different phenotypes. Cluster analysis of CyTOF data is important for.