41. THIBAUT ROSAY
Information acquired: 2025
THIBAUT ROSAY is an academic who published a paper in 2013 entitled TypA is involved in virulence, antimicrobial resistance and biofilm formation in Pseudomonas aerugin. THIBAUT ROSAY published this work as part of a team: Neidig, Anke. Here is a description of this work: Bac,,ground: Pseudomonas aeruginosa is an important opportunistic human pathogen and is extremely difficult to treat due to its high intrinsic and adaptive antibiotic resistance, ability to form biofilms in chronic infections and broad arsenal of virulence factors, which are finely regulated. TypA is a GTPase that has recently been identified to modulate virulence in enteric Gram-negative pathogens. Results: Here, we demonstrate that mutation of typA in P. Aeruginosa resulted in reduced virulence in phagocytic amoebae and human macrophage models of infection. In addition, the typA mutant was attenuated in rapid cell attachment to surfaces and biofilm formation, and exhibited reduced antibiotic resistance to ss-lactam, tetracycline and antimicrobial peptide antibiotics. Quantitative RT-PCR revealed the down-regulation, in a typA mutant, of import.