33. TAMMY-LEE ROMANUIK
Information acquired: 2025
TAMMY-LEE ROMANUIK is an academic who published a paper in 2008 entitled Gene expression in prostate cancer. TAMMY-LEE ROMANUIK published this work as part of a team: Romanuik, Tammy Lee. Here is a description of this work: Development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using Long Serial Analysis of Gene Expression (L0ngSAGE) libraries. We identified 35 genes with novel associations to androgen signalling and validated 24 of these genes using quantitative real time-polymerase chain reaction (qRT-PCR). These genes were: ARL6IF5, BL VRB, C]9orf48, C]orfJ22, C6orf66, CAMK2NJ, CCNI, DERA, ERRFI], GLUL, GOLFH3, HMJ3, HSP9OB], MANEA, NANS, NIPSNAP3A, SLC4JA], SOD], SVIF, TAOK3, TCP], TMEM66, USP33, and VTAJ. The physiological relevance of these expression trends was evaluated in vivo using the LNCaP Hollow Fibre model. There is no cure for castration-recurrent prostate cancer (CRPC), and the mechanisms underlying.