33. ANDREI ROMAN ♂
Information acquired: 2025
ANDREI ROMAN is an academic who published a paper in 2023 entitled Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein. ANDREI ROMAN published this work as part of a team: Gibbs, Ebrima. Here is a description of this work: Mis,,olded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and soluble fibrils have been shown to mediate neurotoxicity and cell-to-cell propagation of pathology. To generate antibodies capable of selectively targeting pathogenic forms of α-Syn, computational modeling was used to predict conformational epitopes likely to become exposed on oligomers and small soluble fibrils, but not on monomers or fully formed insoluble fibrils. Cyclic peptide scaffolds reproducing these conformational epitopes exhibited neurotoxicity and seeding activity, indicating their biological relevance. Immunization with the conformational epitopes gave rise to monoc.