6. HAIDE RAZAVY
Information acquired: 2025
HAIDE RAZAVY is an academic who published a paper in 2023 entitled Suspension culture improves iPSC expansion and pluripotency phenotype. HAIDE RAZAVY published this work as part of a team: Cuesta-Gomez, Nerea. Here is a description of this work: Abs,,ract Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of these regenerative cell therapies requires cost-efficient mass manufacturing of high-quality human iPSCs. This study presents an improved three-dimensional Vertical-Wheel® bioreactor (3D suspension) cell expansion protocol with comparison to a two-dimensional (2D planar) protocol. Methods Sendai virus transfection of human peripheral blood mononuclear cells was used to establish mycoplasma and virus free iPSC lines without common genetic duplications or deletions. IPSCs were then expanded under 2D planar and 3D suspension culture conditions. We comparatively evaluated cell expansion capacity, genetic integrity, pluripotency phenotype, and.