Locate family members with the last name RAMIREZ-MALULE.

Howard Ramirez-Malule is an academic who published a paper in 2024-09-27 entitled Biopolymers as Sustainable and Active Packaging Materials: Fundamentals and Mechanisms of Antifungal Activities. The paper was published in a journal entitled Biomolecules.

HOWARD RAMIREZ-MALULE is an academic who published a paper in 2018 entitled Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and. HOWARD RAMIREZ-MALULE published this work as part of a team: Ramirez-Malule, Howard. Here is a description of this work: Clavulanic acid (CA) is produced by Streptomyces clavuligerus (S. clavuligerus) as a secondary metabolite. Knowledge about the carbon flux distribution along the various routes that supply CA precursors would certainly provide insights about metabolic performance. In order to evaluate metabolic patterns and the possible accumulation of tricarboxylic acid (TCA) cycle intermediates during CA biosynthesis, batch and subsequent continuous cultures with steadily declining feed rates were performed with glycerol as the main substrate. The data were used to in silico explore the metabolic capabilities and the accumulation of metabolic intermediates in S. clavuligerus. While clavulanic acid accumulated at glycerol excess, it steadily decreased at declining dilution rates; CA synthesis stopped when glycerol became the limiting s.