3. ANNA PRUDOVA ♀
Information acquired: 2025
ANNA PRUDOVA is an academic who published a paper in 2020 entitled Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase. ANNA PRUDOVA published this work as part of a team: Tharmarajah, Grace T.. Here is a description of this work: The mouse tail has an important role in the study of melanogenesis, because mouse tail skin can be used to model human skin pigmentation. To better understand the development of melanocytes in the mouse tail, we cloned two dominant ENU-generated mutations of the Adamts9 gene, Und3 and Und4, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the mouse. Adamts9 encodes a widely expressed zinc metalloprotease with thrombospondin type 1 repeats with few known substrates. Melanocytes are lost in the Adamts9 mutant tail epidermis at a relatively late stage of development, around E18.5. Studies of our Adamts9 conditional allele suggest that there is a melanocyte cell autonomous requirement for Adamts9. In addition, we used a proteomics approach, TAILS N-terminomics, to iden.