4. FRANCESCA PAPACCI ♀
Information acquired: 2025
FRANCESCA PAPACCI is an academic who published a paper in 2017 entitled Naringenin as a novel inhibitor of Two-Pore Channel 2 controlling the angiogenic process in vitro an. FRANCESCA PAPACCI published this work as part of a team: Papacci, Francesca. Here is a description of this work: Two,,Pore Channels (TPCs) are an emerging family of intracellular channels, expressed on acidic compartments, which mediate calcium signaling evoked by NAADP. In particular, we demonstrated that TPC2 isoform has a main role in angiogenesis (Favia et al. PNAS 2014 Nov 4,111 (44) :E4706-15). TPC2 inhibition is emerging as a key therapeutic step in a range of important pathological conditions including the progression and metastatic potential of cancer, Parkinson's disease, and Ebola virus infection. We introduce naringenin, a natural flavonoid, as a novel TPC2 inhibitor as shown by electrophysiological evidence in a heterologous system, i.E. Arabidopsis vacuoles lacking endogenous TPCs. In view of the control exerted by TPC2 on intracellular calcium signaling and angiogenesis, we demonstrate that naringenin dampens intracellular ca.