5. ALICE-FEDERICA OSSOLI
Information acquired: 2025
ALICE-FEDERICA OSSOLI is an academic who published a paper in 2014 entitled ROLE OF ABNORMAL LIPOPROTEINS IN ATHEROSCLEROSIS AND RENAL DISEASE IN LCAT DEFICIENCY. ALICE-FEDERICA OSSOLI published this work as part of a team: OSSOLI, ALICE FEDERICA. Here is a description of this work: The lecithin:cholesterol acyltransferase (LCAT) is the unique enzyme in human plasma responsible for the synthesis of cholesteryl esters and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by abnormal plasma lipoprotein profile characterized by low HDL level, mainly small discoidal pre-beta particles, and by presence of LpX, an abnormal lipoprotein usually absent in normal plasma and detectable only in some pathological cases. The impact of LCAT on human atherogenesis is controversial. Furthermore, the cause of renal disease, the major cause of morbidity and mortality in LCAT deficient patients, is poorly understood. Aim of my project was to analyze the peculiar characteristic of abnormal lipoprotein accumulated in LCAT deficient subjects and ev.