Locate family members with the last name MATYUGINA.

E.G. MATYUGINA is an academic who is affiliated with National Research Tomsk State University, Tomsk State University of Control Systems and Radioelectronics.

Elena Matyugina is an academic who published a paper in 2023-02-08 entitled Nucleoside Analogs That Inhibit SARS-CoV-2 Replication by Blocking Interaction of Virus Polymerase with RNA. The paper was published in a journal entitled International Journal of Molecular Sciences.

ELENA MATYUGINA is an academic who published a paper in 2023 entitled Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP. ELENA MATYUGINA published this work as part of a team: Khandazhinskaya, Anastasia. Here is a description of this work: The,,great interest in studying the structure of human purine nucleoside phosphorylase (hPNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition, hPNP inhibitors are used in organ transplant surgeries to provide immunodeficiency during and after the procedure. Previously, we showed that members of the well-known fleximer class of nucleosides are substrates of E. Coli PNP. Fleximers have great promise as they have exhibited significant biological activity against a number of viruses of pandemic concern. Herein, we describe the synthesis and inhibition studies of a series of new fleximer compounds against hPNP and discuss their possible binding mode with the enzyme. At a concentration of 2 mM for the flex-7-deazapurines 1â€"4, a decrea.

Elena S. Matyugina is an academic who published a paper in 2021-07-13 entitled Dual-targeted anti-CMV/anti-HIV-1 heterodimers. The paper was published in a journal entitled Biochimie.

ELENA-S. MATYUGINA is an academic who published a paper in 2018 entitled Nov,,l 5′-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents. ELENA-S. MATYUGINA published this work as part of a team: Khandazhinskaya, Anastasia L.. Here is a description of this work: A s,,ries of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of Mycobacterium smegmatis was completely inhibited by the most active compounds at a MIC99 of 67 μg/mL (mc2155) and a MIC99 of 6. 7â€"67 μg/mL (VKPM Ac 1339). Several compounds also showed the ability to inhibit the growth of attenuated strains of Mycobacterium tuberculosis ATCC 25177 (MIC99 28â€"61 μg/mL) and Mycobacterium bovis ATCC 35737 (MIC99 50â€"60 μg/mL), as well as two virulent strains of M. Tuberculosis, a laboratory strain H37Rv (MIC99 20â€"50 μg/mL) and a clinical strain with multiple drug resistance MS-115 (MIC99 20â€"50 μg/mL). Transmission electron microscopy (TEM) evaluation of M. Tuberculosis.

E. S. Matyugina is an academic who published a paper in 2024 entitled 5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia. The paper was published in a journal entitled Acta Naturae.