9. VEGA MASIGNANI
Information acquired: 2025
VEGA MASIGNANI is an academic who published a paper in 2010 entitled Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.. VEGA MASIGNANI published this work as part of a team: Donati, Claudio. Here is a description of this work: BACKGROUND: Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group. RESULTS: Despite evidence of extensive recombination, the S. pneumoniae phylogenetic tree revealed six major lineages. With the exception of serotype 1, the tree correlated poorly with capsular serotype, geographical site of isolation and disease outcome. The distribution of dispensable genes--genes present in more than one strain but not in all strains--was consistent with phylogeny, although horizontal gene transfer events attenuated this correlation in the case of ancient lineages. Homologous recombination, involving short stretches of DNA, was the dominant evolutionary process of the cor.