1. RICCARDO MASETTI
Information acquired: 2025
RICCARDO MASETTI is an academic who published a paper in 2015 entitled Stearoyl-CoA desaturase 1 and paracrine signal involvement in the promotion of breast cancer cell mi. RICCARDO MASETTI published this work as part of a team: Angelucci, Cristiana. Here is a description of this work: Despite the acknowledged impact of the tumor stroma on breast cancer development and progression, the molecular basis of such effects remain partially unexplained. We previously reported that breast cancer-associated fibroblasts (CAFs) induced epithelial-mesenchymal transition and an increase in cell membrane fluidity and migration speed in poorly (MCF-7) and highly invasive (MDA-MB-231) breast cancer cells. More recently, in order to better define the mechanisms responsible for the CAF-promoted tumor cell migration, we investigated the role of Stearoyl-CoA desaturase 1 (SCD1), the main enzyme regulating membrane fluidity, and demonstrated its CAF-triggered up-regulation as well as its crucial role in the migratory ability of the above tumor cells. Besides SCD1 induction, a CAF-promoted enhancement in the prote.
