2. EDUARD MAS CLARET ♂
Information acquired: 2025
EDUARD MAS CLARET is an academic who published a paper in 2020 entitled Design and synthesis of pyrrolidine-based nucleotide mimetics for use as inhibitors of the DNA repai. EDUARD MAS CLARET published this work as part of a team: Mas Claret, Eduard. Here is a description of this work: The action of the DNA repair enzyme alkyladenine DNA glycosylase (AAG), as part of the Base Excision Repair pathway, on alkylation-induced DNA damage has been shown in mice to lead to cell death in the retina, spleen, thymus and cerebellum. The action of AAG has also been linked to damage caused by ischaemia/reperfusion (I/R) events in liver, brain and kidney. As a result, small molecule inhibitors of AAG are required for ongoing studies into the biological mechanism of this cellular damage, as well as to become potential drug leads for some types of retinal degeneration, I/R-related tissue damage, or as protective agents for patients undergoing alkylative chemotherapy and showing an increased AAG activity. They could also serve the opposite effect, acting as an alkylating agent (TMZ) sensitiser in paediatric glioblastoma (GBM). Two.