7. PIETRO LO RISO
Information acquired: 2025
PIETRO LO RISO is an academic who published a paper in 2016 entitled INDUCED PLURIPOTENT STEM CELLS: AN INNOVATIVE TOOL TO DISSECT OVARIAN CANCER PATHOGENESIS. PIETRO LO RISO published this work as part of a team: LO RISO, PIETRO. Here is a description of this work: Ovarian cancer (OC) has one of the highest death-to-incidence ratios among all tumor types, which points to the need for novel therapeutic and prognostic strategies. Indeed, the absence of relevant tumor cell lines that can recapitulate disease histopathology highlights an acute need for new model systems to study this pathology. In particular, it is still unclear whether the most common and aggressive form of this disease, high grade serous ovarian cancer (HGSOC), could arise from in the ovarian surface epithelium (OSE), as initially thought, or might be arising from the fimbrial epithelium. Here I addressed these issues in two complementary ways based on induced pluripotent stem cells: i) the modeling of Ovarian Cancer by somatic cell reprogramming to pluripotency of tumor cells; ii) the molecular characterization of HGSOC and its.