50. PAMELA-JOAN LINCEZ
Information acquired: 2025
PAMELA-JOAN LINCEZ is an academic who published a paper in 2015 entitled MDA5 and a type 1 interferon signature in the development of type 1 diabetes. PAMELA-JOAN LINCEZ published this work as part of a team: Lincez, Pamela Joan. Here is a description of this work: Typ,, 1 diabetes (T1D) is a debilitating disease involving the autoimmune destruction of insulin-producing pancreatic β-cells. The personal and economic burden of this disease is enormous, therefore simpler and more cost effective therapeutic approaches than those currently available must be explored. In children at risk for T1D, a unique type 1 interferon (IFN-I) transcriptional signature precedes islet autoimmunity. Recent onset of T1D strongly associates with infection by RNA viruses like coxsackievirus that induce IFN-I. Importantly, genetic variants in the T1D risk locus IFIH1 are linked to protection from T1D and result in reduced expression of the RNA virus sensor melanoma differentiation-associated protein 5 (MDA5), which is also a critical component in establishing the IFN-I signature. In chapter 2 we describe a novel model where we hav.