45. YVES LEDUC
Information acquired: 2025
YVES LEDUC is an academic who published a paper in 1993 entitled The role of glycosaminoglycans in binding of herpes simplex virus type 1 to mammalian cells. YVES LEDUC published this work as part of a team: Leduc, Yves. Here is a description of this work: Bin,,ing of herpes simplex virus type 1 (HSV-1) to the cell surfaces initially requires interactions between viral glycoproteins embedded in the viral envelope and cell surface glycosaminoglycans (GAGs). In this work, mutant cells derived from Ltkâ» murine fibroblasts and devoid of the cell surface GAG heparan sulfate (HS) (gro2C cells) or HS and chondroitin sulfate (CS) (sog9 cells) were used to study the importance of these GAGs in HSV-1 binding. HSV-1 plaque formation and binding, as assessed by the use of radiolabeled virions, were reduced by approximately 85% with gro2C cells relative to parental L cells. This indicated that cell surface HS is important but not essential for HSV-1 binding. Addition of soluble forms of HS and, to a lesser extent, CS types A, B (both 4-sulfated), and C (6, sulfated) blocked adsorption of HSV-1 to g.