56. SIMONE KOSOL
Information acquired: 2025
SIMONE KOSOL is an academic who published a paper in 2022 entitled The occurrence of ansamers in the synthesis of cyclic peptides. SIMONE KOSOL published this work as part of a team: Yao, Guiyang. Here is a description of this work: α-,,manitin is a bicyclic octapeptide composed of a macrolactam with a tryptathionine cross-link forming a handle. Previously, the occurrence of isomers of amanitin, termed atropisomers has been postulated. Although the total synthesis of α-amanitin has been accomplished this aspect still remains unsolved. We perform the synthesis of amanitin analogs, accompanied by in-depth spectroscopic, crystallographic and molecular dynamics studies. The data unambiguously confirms the synthesis of two amatoxin-type isomers, for which we propose the term ansamers. The natural structure of the P-ansamer can be ansa-selectively synthesized using an optimized synthetic strategy. We believe that the here described terminology does also have implications for many other peptide structures, e.G. Norbornapeptides, lasso peptides, tryptorubins and others, and helps to unambiguously desc.