52. MATTHEOS KOFFAS
Information acquired: 2025
MATTHEOS KOFFAS is an academic who published a paper in 2020 entitled Biotechnological production of flavonoids: an update on plant metabolic engineering, microbial host. MATTHEOS KOFFAS published this work as part of a team: Marsafari, Monireh. Here is a description of this work: Flavonoids represent a diversified family of phenylpropanoid-derived plant secondary metabolites. They are widely found in fruits, vegetables and medicinal herbs and plants. There has been increasing interest on flavonoids because of their proven bioactivity associated with anti-obesity, anti-cancer, anti-inflammatory, anti-diabetic activity and the prevention of aging-related chronic conditions, such as nervous and cardiovascular disease. Low bioavailability of flavonoids is a major challenge restricting their wide applications. Due to safety and economic issues, traditional plant extraction or chemical synthesis could not provide a scalable route for large-scale production of flavonoids. Alternatively, reconstruction of biosynthetic gene clusters in plants and industrially relevant microbes offer significant promise.