6. JAMES-MCLEOD FORRESTER
Information acquired: 2025
JAMES-MCLEOD FORRESTER is an academic who published a paper in 1972 entitled Topics in natural product synthesis and biosynthesis. JAMES-MCLEOD FORRESTER published this work as part of a team: Forrester, James McLeod. Here is a description of this work: In ,,art I of this thesis is described the syntheses of radiolabelled âˆ-bisabolene, monocyclofarnesol and farnesol-10, 11-epoxide, and the evaluation of their role as precursors of the mould metabolite trichothecin. âˆ-Bisabolene was prepared by dehydration of radiolabelled âˆ-bisabolol, which itself was prepared by the action of ¹â'C-methyl magnesium iodide on 2-methyl-6-keto-6, (4'-methylcyclohex-3'-enyl) -hex-2-ene. This ketone was prepared in a modified Grignard reaction from 5-bromo-2-methyl-pent-2-ene, (obtained from cyclopropyl methyl ketone by treatment with methyl magnesium iodide followed by reaction of the intermediate 2-cyclopropylpropan-2-ol with 48% hydrogen bromide) and 4-methylcyclohex-3-ene carboxylic acid (prepared in a Diels Alder reaction between acrylic acid, or its methyl ester, and isoprene). Monocyclofarnesol was prepared from β-ionone.