14. DANIEL-JOHN FORNIKA
Information acquired: 2025
DANIEL-JOHN FORNIKA is an academic who published a paper in 2012 entitled Mitochondrial genome variation in healthy aging. DANIEL-JOHN FORNIKA published this work as part of a team: Fornika, Daniel John. Here is a description of this work: Mit,,chondria are thought to play a role in the aging process through their production of reactive oxygen species (ROS), and their regulation of cell fate via senescence and apoptosis. We hypothesize that genetic variation in the mitochondrial genome may explain a portion of the phenotypic variance in the development of long-term good health. To test this hypothesis, we have performed genetic association tests on a set of common mitochondrial polymorphisms, in a study of 419 exceptionally healthy seniors (cases) and 415 population-based mid-life individuals (controls). Variant discovery was performed using Sanger sequencing of 834 individuals for the 1. 1 kb non-coding mitochondrial control region, and identiï¬ed 277 SNPs present in at least one individual. A set of 92 mitochondrial coding-region SNPs were chosen via pooled high-throughput sequencing, combined with a previ.