12. CHRISTOPHER-JOSEPH DOLL
Information acquired: 2025
CHRISTOPHER-JOSEPH DOLL is an academic who published a paper in 1993 entitled Mechanisms of anoxia tolerance in the turtle cortex. CHRISTOPHER-JOSEPH DOLL published this work as part of a team: Doll, Christopher Joseph. Here is a description of this work: The,,high sensitivity of the mammalian brain and the insensitivity of the turtle brain to Oâ‚‚ deprivation led to the use of cortical slice preparations in both species being utilized for a comparative study of anoxia tolerance. To assess anoxic survival, intracellular recording techniques were employed. Turtle neurons survived both anoxia (aCSF equilibrated with 95% N2 /5 % COâ‚‚) and pharmacological anoxia (anoxia 1mM NaCN) for 180 min. With no measurable degradation. Rat pyramidal neurons responded with a decrease in whole cell resistance followed by transient hyperpolarization and a subsequent depolarization to a zero membrane potential (41. 3 ± 6. 5 min. anoxia, 25. 8 ± 12. 6 min. pharmacological anoxia). Pharmacological ischemia (pharmacological anoxia iodoacetate 10 mM) caused a rapid decrease in whole cell resistance, transient hyperpolarization, and a r.