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BARBARA-LELJ-GAROLLA DI BARD is an academic who published a paper in 2011 entitled Self-association and chaperon activity of the small heat shock protein 27. BARBARA-LELJ-GAROLLA DI BARD published this work as part of a team: Di Bard, Barbara Lelj Garolla. Here is a description of this work: Human Hsp27 is a member of the small heat shock protein family that is over-expressed during cellular stress and that is involved in biological functions ranging from inhibition of apoptosis to regulation of cellular glutathione levels. In addition, Hsp27 is an ATP-independent molecular chaperon that binds to unfolding peptides and inhibits their precipitation. Roles for Hsp27 in several human diseases have also been proposed. For example, the expression of Hsp27 by several human tumors has been noted as a potential diagnostic feature or a therapeutic target. Increasing evidence indicates that the biological functions of Hsp27 are linked to the reversible self-association of the protein to form large oligomers in a process that is at least in part regulated by reversible phosphorylation of three Ser residues. The three-dimensional structur.