58. CHRISTOPHER-F. BASLER
Information acquired: 2025
CHRISTOPHER-F. BASLER is an academic who published a paper in 2023 entitled Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. CHRISTOPHER-F. BASLER published this work as part of a team: Donnelly, Camilla M.. Here is a description of this work: Nip,,h virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the Henipavirus genus within the paramyxovirus family and are harbored by Pteropus Flying Fox species. Henipaviruses cause severe respiratory disease, neural symptoms, and encephalitis in various animals and humans, with human mortality rates exceeding 70% in some NiV outbreaks. The henipavirus matrix protein (M), which drives viral assembly and budding of the virion, also performs non-structural functions as a type I interferon antagonist. Interestingly, M also undergoes nuclear trafficking that mediates critical monoubiquitination for downstream cell sorting, membrane association, and budding processes. Based on the NiV and HeV M X-ray crystal structures and cell-based assays, M possesses a putative monopartite nuclear localization.